Green Buckeye RN

EHN: BPA and a Common Phthalate May Contribute to Obesity, Predicts a Cell Test
September 21, 2010, 10:08 am
Filed under: News

Sep 15, 2010

Wang, Y.-F., H-R. Chao, C-H. Wu, C-H Tseng, Y-T Kuo and T-C Tsou. 2010. A recombinant peroxisome proliferator response element-driven luciferase assay for evaluation of potential environmental obesogens.  Biotechnology Letters
Synopsis by Laura Vandenberg

Two widely used chemicals are implicated in obesity after they reacted with specially-made cells and influenced fat cell development and fat storage – two underlying factors in weight gain.

Chemicals that can influence obesity may now be easier to identify, thanks to a new cell test that can pinpoint the guilty compounds. Using the test, researchers identified two common environmental chemicals – bisphenol A and benzyl butyl phthalate – that can modulate the signals controlling the number of fat cells produced and the uptake and storage of fats in those cells.

Both of these conditions – more fat cells and fatter cells – underlie weight gain in people. Until now, there was no easy way to predict if a chemical could alter cell function to cause obesity. The newly developed cell line may be helpful for screening large numbers of environmental chemicals that could be selected for future study or to identify heavily-used chemicals that need stricter regulation.

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