Green Buckeye RN

EHN: Silver Nanoparticles Stop Sperm Stem Cell Growth
September 1, 2010, 1:08 pm
Filed under: News

Sep 01, 2010

Braydich-Stolle, LK, B Lucas, A Schrand, RC Murdock, T Lee, J Schlager, S Hussain, and M-C Hofmann. 2010. Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. Toxicological Scences
Synopsis by Jennifer F. Nyland

A new study has identified exactly how silver nanoparticles cause male reproductive cells to stop growing.

Minute materials used in a number of consumer products such as antimicrobial agents can interrupt important cell signaling within male reproductive sperm cells, causing them to stop growing, according to a new study that builds on previous work by the same research group.

In prior studies, the scientists reported how smaller-sized silver nanoparticles – in the 10 – 25 nanometer range – decreased the growth of male stem cells when they were exposed at concentrations greater than 10 micrograms per milliliter (ug/ml).

The new study is the first to identify how the silver nanoparticles stop the sperm stem cells from growing. The biggest effects were caused by the smallest-sized nanoparticles tested.

This study raises important questions about potential effects on male fertility, because silver nanoparticles are currently used in a wide range of products.

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